Table 1.
Fold induction of p53-related genes in the ALS model SOD1 (G86R).
| Gene name | Function | 90 d. | 105 d. |
|---|---|---|---|
| p53-family target genes | |||
| Cdkn1a (p21) | Cell cycle arrest | 4 | 13 |
| Gadd45a | Cell cycle arrest | 5,6 | 21 |
| Peg3 | Apoptosis inducing | 3 | 7 |
| Perp | Cell cycle arrest | 4 | 12 |
| Pmaip1 | Apoptosis effector | 5 | 12 |
| Bax | Apoptosis effector | 3 | 8 |
| Siva | Apoptosis inducing | 3 | 5 |
| Zmat3 | Growth regulation | 1,6 | 1,1 |
| Eda2R | NF.Kb/JNK pathway | 3,4 | 9,4 |
| Tigar | Glucose metabolism | 0,75 | 0,2 |
| Sens1 | ROS homeostasis | - | 16,3 |
| Sens2 | ROS homeostasis | 1,27 | 1,46 |
| Sco2 | Glucose metabolism | 1,18 | 0,91 |
| Ddit3 (Chop) | ER stress | 1,14 | 0,35 |
| Bip (Grp78) | ER stress | 1,25 | 1,08 |
| Xbp1 | ER stress | 2 | 2,51 |
| p53-family regulators | |||
| Mlf1 | Cell cycle arrest/differentiation | 0,9 | 0,2 |
| Myf6 | Differentiation | 4 | 7 |
| Mdm2 | p53 degradation | 4 | 6 |
| Txn1 | Oxidative stress response | 4 | 6 |
| Id2 | Inhibition of differentiation | 2 | 3,1 |
| p53-family members | |||
| P53 | 4 | 3 | |
| TAp63 | 4 | 12 | |
| ∆Np63 | 0,5 | 0,3 | |
| TAp73 | 2 | 3 | |
| ∆Np73 | 0,9 | 0,8 | |
| Denervation/atrophy markers | |||
| Chrna1 (ACh Receptor alpha) | Neuromuscular junction | 4,2 | 12,4 |