Table 2.
β-Layers in proteins of known structure.
| Cellular proteins (canonical) | ||||||
|---|---|---|---|---|---|---|
| PDB | Type | Protein | Domain | Species | Sequence | Similar structures |
| 2YO3 | cc-to-β | SadA | TAA DALL1 | Salmonella enterica |
abcdefgβββEEEECC
1306-LKASEAGSVRYETNAD-1321 |
3WPA, 3WPO, 3WPP, 3WQA (Acinetobacter sp. Tol5), 4USX (Burkholderia pseudomallei) |
| 2YO2 | cc-to-β | SadA | TAA DALL2 | Salmonella enterica |
abcdefgβββEECCC
310-VAGLAEDALLWDESI-324 |
3ZMF, 2YNZ (Salmonella enterica) |
| 2YO3 | β-to-cc | SadA | TAA Short neck | Salmonella enterica |
EEEECCCβββefgabcdefghijklmno
1345-AAVNDTDAVNYAQLKRSVEEANTYTDQK-1372 |
4LGO (Bartonella quintana), 3WP8, 3WPA, 3WPR (Acinetobacter sp. Tol5), 1P9H (Yersinia enterocolitica), 2XQH (Escherichia coli), 3D9X (Bartonella henselae), 2YO0 (Salmonella enterica), 3S6L, 4USX (Burkholderia pseudomallei), 2GR7 (Haemophilus influenzae) |
| 2YO2 | β-to-cc | SadA | TAA Long neck | Salmonella enterica |
EEEEβββefgabcdefg
349-DSTDAVNGSQMKQIEDK-365 |
2YNZ, 3ZMF (Salmonella enterica), 3EMO (Haemophilus influenzae), 3LAA, 3LA9, 4USX (Burkholderia pseudomallei), 3WPA, 3WPO, 3WPP, 3WPR, 3WQA (Acinetobacter sp. Tol5), 3NTN, 3PR7 (Moraxella catarrhalis) |
| 1S7M | β-to-cc | Hia | TAA Insert neck 1 | Haemophilus influenzae |
EEβββefgabc
642-NTAATVGDLRG-652 |
3EMF (Haemophilus influenzae) |
| 4C47 | Nterm-to-cc | SadB | - | Salmonella enterica |
CCβββefgabcdefg
23-DYFADKHLVEEMKEQ-37 |
- |
| 5APP | cc-to-cc | OMP100 | TAA Stalk | Actinobacillus actinomycetemcomitans |
abcdefgabcβββefgabcdefg
153-IAENKKAIENKADKADVEKNRAD-175 |
- |
| 5APZ | cc-to-cc | Tcar0761 | DUF3782 | Thermosinus carboxydivorans |
abcdefgβββefgabc
68-ITLMQANMATKDDLAR-83 |
- |
| 2BA2 | Nterm-to-cc | MPN010 | DUF16 | Mycoplasma pneumoniae |
CCCβββefghijk
5-GTRYVTHKQLDEK-17 |
- |
| 2BA2 | cc-to-cc | MPN010 | DUF16 | Mycoplasma pneumoniae |
hijkabcβββefgabcdefghijk
14-LDEKLKNFVTKTEFKEFQTVVMES-37 |
- |
| 3PYW | coil-to-cc | S-layer protein Sap | SLH | Bacillus anthracis |
CCCCEβββefghijkabcdef
35-FEPGKELTRAEAATMMAQILN-55 ... 94-FEPNGKIDRVSMASLLVEAYK-114 ... 156-WEPKKTVTKAEAAQFIAKTDK-176 |
- |
| Phage and virus proteins (canonical) | ||||||
| 2C3F | cc-to-cc | Tail fiber hyaluronidase | - | Streptococcus pyogenes (prophage SF370.1) |
abcβββefghijkabcβββefgβββefghijk
69-IDGLATKVETAQKLQQKADKETVYTKAESKQE-99 |
2DP5 (Streptococcus pyogenes) |
| 2C3F | cc-to-β | Tail fiber hyaluronidase | - | Streptococcus pyogenes (prophage SF370.1) |
defgabcβββCEEEEE
97-SKQELDKKLNLKGGVM-112 |
2DP5 (Streptococcus pyogenes) |
| 2C3F | β-to-cc | Tail fiber hyaluronidase | TAA short neck homolog | Streptococcus pyogenes (prophage SF370.1) |
EEEECCEβββefghijkabcdefg
310-DPTANDHAATKAYVDKAISELKKL-327 |
2DP5, 2WH7, 2WB3 (Streptococcus pyogenes) |
| 4MTM | coil-to-cc | gp53 | - | Bacteriophage AP22 |
CCCCEβββefgabcdefg
155-NDVGSALSAAQGKVLNDK-172 |
- |
| 1YU4 | β-to-cc | Major tropism determinant U1 variant (Mtd-U1) | - | Bordetella Phage BMP-1 |
CCCCEEβββefgab
41-TAGGFPLARHDLVK-54 |
- |
| 1TSP | cc-to-β | Tailspike protein | Phage P22-tail | Phage P22 |
defghijkβββEEE
113-YSIEADKKFKYSVK-126 |
1CLW, 2XC1, 2VFM, 2VFP, 2VFQ, 2VFO, 2VFN [...] (Phage P22) 4OJP, 4OJ5, 4OJL [...] (E. coli Bacteriophage CBA120) 2V5I (Bacteriophage Det7), 2X3H (Enterobacteria phage K1-5) |
| 2POH | cc-to-β | Phage P22 tail needle gp26 | - | Phage P22 |
abcdefgβββCEEC
133-ISALQADYVSKTAT-146 |
3C9I, 4LIN, 4ZKP, 4ZKU, 5BU5, 5BU8, 5BVZ (Phage P22) |
| 1H6W | β-to-cc | Short fiber | Receptor binding domain | Bacteriophage T4 |
EEEEEECCEEβββefgabcde
321-MTGGYIQGKRVVTQNEIDRTI-341 |
1OCY, 1PDI, 2XGF, 2FKK, 2FL8 (Bacteriophage T4) |
| 4A0T | cc-to-coil | gp17 | gp37_C | Bacteriophage T7 |
cdefghijkβββCCCC
454-WLDAYLRDSFVAKSKA-469 |
4A0U (Bacteriophage T7) |
| 1MG1 | α-to-cc | Maltose-binding protein GP21 | TLV_coat | Primate T-lymphotrophic virus 1 (HTLV-1) |
HHHHHHEβββefgabcdefghijk
364-AAQTNAAAMSLASGKSLLHEVDKD-387 |
- |
| 3DUZ | coil-to-cc | GP64 | Baculo_gp64 | Autographa californica Multiple Nucleopolyhedrovirus |
CCCβββefgabcdefg
293-EGDTATKGDLMHIQEE-308 |
- |
| 4NKJ | Nterm-to-cc | Hemagglutinin | Hemagglutinin HA2 | Influenza B virus |
Eβββefgabcdefghijk
4-VAADLKSTQEAINKITKN-21 |
1QU1 (Influenza A virus) |
| Unusual β-layer proteins | ||||||
| 4NQJ | α-to-α | TRIM Ubiquitin E3 ligase | DUF3583 | Homo sapiens |
HHHHHHHβββHHHHHHH
143-SVGQSKEFLQISDAVHF-159 |
- |
| 2F0C | (cc-to-)coil-to-β | Receptor binding protein (ORF49) | - | Lactophage tp901-1 |
abcdefgabCCCCβββCEEC
22-LEAINSELTSGGNVVHKTGD-41 |
3D8M, 3DA0 (Lactophage tp901-1) |
| 1AA0 | (cc-to-)coil-to-β | Fibritin | Fibritin_C | Bacteriophage T4 |
abcdefgCβββEEEEE
450-VQALQEAGYIPEAPRD-465 |
1AVY, 2BSG, 2IBL, 2WW6, 2WW7, 3ALM (Bacteriophage T4), 5C0R (Influenza A), 2LP7 (Human Immunodeficiency Virus 1), 1NAY |
| 2XGF | coil-to-coil | Long tail fiber needle | - | Bacteriophage T4 |
EEEECCCCCCCCβββCCCCEEEE
934-EAWNGTGVGGNKMSSYAISYRAG-956 |
- |
| 1H6W | coil-to-coil-(to-β) | Short fiber | - | Bacteriophage T4 |
CCCβββCCCCEEEEE
284-NADVIHQRGGQTING-298 |
- |
| 4UXG | β-to-coil | Proximal long tail fibre protein gp34 | - | Bacteriophage T4 |
EEEβββCCCCCC
1233-FVQVFDGGNPPQ-1244 |
- |
| 4UXG | α-to-coil | Proximal long tail fibre protein gp34 | - | Bacteriophage T4 |
HHHHCβββCCCEEE
1245-PSDIGALPSDNATM-1258 |
- |
| 3QC7 | α-to-coil | Head fiber | - | Bacteriophage Phi29 |
HHHHHHHβββCCCCCCC
221-NLRTMIGAGVPYSLPAA-237 |
- |