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Hsp90 inhibitors, e.g., geldanamycin (GA), have been shown to bind to the ATP pocket of Hsp90, which disturbs the binding of Hsp90 to HSF1 and alters Hsp70 gene expression. Hsp70 is a potent negative regulator of inflammatory responses through, but not limited to, its negative feedback effect on NF-κB signaling pathway (Stocki and Dickinson 2012; Wieten et al. 2007; Collins et al. 2013; Tukaj et al. 2014b, c)
