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. 2016 Mar 11;10:62. doi: 10.3389/fncel.2016.00062

Figure 2.

Figure 2

Migration of ventrally derived hindbrain neurons. (A) Sagittal view of embryonic brain. Red lines indicate level of coronal section in (C–H). (B) Expression of Reelin, Dab1 and ApoER2 over time. (C–E) Expression patterns of Reelin (red), Dab1 (yellow) and ApoER2 (blue) at the indicated time point. Reelin and Dab1 expression are only presented in the left half of the brain, ApoER2 expression is only presented in the right half of the brain. Question mark indicates a lack of expression data. The VLDLR expression pattern is not well characterized in the hindbrain, thus it is not included in the schematics in (B–E). (F–H) Schematics of migratory paths of cochlear efferent nucleus (CEN) neurons, facial visceral motor (FVM) neurons and facial branchial motor (FBM) neurons in the wildtype (left half of the brain) and reeler mutants (right half of the brain). Red arrows indicate dorsolateral tangential migration, black arrows indicate ventral radial migration, and blue arrows indicate rostrocaudal migration. (F,G) Ventral migration of CEN and FVM neurons is truncated in reeler mutants. (H,I) The majority of FBM neurons reach their final superficial position in r6 of the hindbrain, but the nuclei shows subtle disorganizations. (I′,I″) The medial lobe (Lhx4+) is reduced (turquoise dots), the lateral lobe (Er81+) is disorganized (dark green dots) in reeler mutants compared to the wildtype.