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Effects of PS1 WT and PS1 Mutants on long Aβ Cleavage in 2EB2 cell line by ELISA (A,B). Conditioned medium from 2EB2 cells expressing empty vector, PS1-WT or FAD PS1 mutants were analyzed for levels of secreted Aβ40 and Aβ42 using ELISA kit. (A) The levels of Aβ40 and Aβ42 are plotted in relative to PS1 WT. (B) The Aβ42/Aβ40 ratio. ∗P < 0.05; ∗∗P < 0.01.
