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. 2016 Mar 11;8:51. doi: 10.3389/fnagi.2016.00051

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Copyright © 2016 Li, Liu, Qiu, Ren, Dai, Deng and Qing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PS-WT1 and PS1 Mutants on long Aβ Cleavage in 2EB2 cell line by LC-MS/MS. (A) Fold changes of the relative rate of Aβ49-40/total Aβ production. (B) Fold changes of the relative VVIA levels in cell lysates of 2EB2 cell line. (C) Fold changes of the relative IAT levels in cell lysates of 2EB2 cells line. (D) Fold changes of the relative VIT, TVI, and VVIA levels in cell line expressing PS1 and PS1 FAD mutants. (E) Fold changes of the relative ITL, VIV, and IAT levels in cell line expressing PS1 and PS1 FAD mutants. ^∗P < 0.05; ^∗∗P < 0.01.