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. 2016 Mar 11;8:51. doi: 10.3389/fnagi.2016.00051

FIGURE 7.

FIGURE 7

Summarize the effects on specific peptides cleaved from long Aβ in different mutations. The APP can be sequential cleavage by β-secretase (BACE1)/α-secretase and γ-secretase. APP-C-terminal fragment is cleaved at the 𝜀-site by γ-secretase, generating primarily long fragments, Aβ48 and Aβ49, followed by stepwise cleavage of every three amino acid residues at the C terminus, generating unique peptide. PS1 negative control, D385A, showed no change in unique peptide VVIA and IAT. Six mutations (I143T, H163P, S170F, Q223R, M233V, and G384A) change the ratio of Aβ42/40 by decreasing the cleavage of Aβ43-40 and Aβ42-38. L166P affect the ratio of Aβ42/40 by decreasing the cleavage of Aβ43-40. Six mutations (I143V, M146V, G217A, E280A, L381V, and L392V) affect the ratio of Aβ42/40 by decreasing the cleavage of Aβ42-38.