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CREB1 interferes with UNG2 enzymatic activity when the CRE site contains a G/U mispair in the CpG islet. In the presence of 85 nm UNG2, 61% ± 5% (n = 3) of U residues within the CRE site were cleaved. However, the presence of 8.5 nm CREB1 together with UNG2 reduced cleavage by 50% ± 3% (n = 3). Error bars represent ± S.E., ***, p ≤ 0.001; **, p ≤ 0.005.
