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Comparative binding affinities of VEGF dual dAb and aflibercept to different human VEGF isoforms
Data are the mean from n = 3 experiments, determined by MSD (numbers in parentheses represent S.D.).
| Molecule | Ligand | EC50 |
|---|---|---|
| pm | ||
| Aflibercept | Human VEGF-A165 | 86 (10.3) |
| VEGF dual dAb | Human VEGF-A165 | 32 (2.7) |
| Aflibercept | Human VEGF-A121 | 317 (83.0) |
| VEGF dual dAb | Human VEGF-A121 | 127 (22.1) |
| Aflibercept | Murine VEGF-A164 | 95 (20.2) |
| VEGF dual dAb | Murine VEGF-A164 | 36 (4.7) |
