FIGURE 6.

Schematic discussion of the Hv gating. A, Schematic illustration of the Trp²⁵⁷ introduction. The scheme shows the coupling energy between the monomer and dimer. The numbers indicate the ΔΔG (blue, activation; red, deactivation). B and C, interaction energy profiles for channel mutation. The criterion for two well correlated residues is a value greater than 0.89. Interaction energies for positions 250, 253, and 257 show strong interaction of the two Trp residues during the deactivation phase.