FIGURE 3.

Pdk2/4 DKO mice display attenuated pain response following diabetes induction. STZ injection reduced paw withdrawal threshold to force. The STZ-induced mechanical hypersensitivity is attenuated in Pdk2/4 DKO mice compared with WT animals up to 4 weeks. *, p < 0.05 versus the WT animals with diabetes, Mann-Whitney and one-way ANOVA with Dunnett's multiple-comparison tests for paw withdrawal threshold, n = 10 (up to 6 weeks) or n = 4 (after 6 weeks); mean ± S.E. (error bars). w, week(s).