Table 1.
Gene expression targets for macrophage phenotypes
| Gene ID | MΦ Type | Gene Title |
|---|---|---|
| ADK | M2 | Adenosine kinase |
| ARG1 | M2 | Arginase 1 |
| ALOX15 | M2 | Arachidonate 15-lipoxygenase |
| BCL2A1 | M1 | BCL2-Related Protein A1 |
| BIRC3 | M1 | Baculoviral IAP Repeat Containing 3, apoptosis regulator |
| CA2 | M2 | Carbonic anhydrase II |
| CCL1 | M2 | Chemokine (C-C motif) ligand 1 |
| CCL2 | M1 | Macrophage chemotactic protein 1 (MCP-1) |
| CCL3 | M1 | Macrophage inflammatory protein 1α (MIP-1α) |
| CCL4L1 | M1 | Chemokine (C-C motif) ligand 4-like 1 |
| CCL5 | M1 | Regulated on activation, normal T cell expressed and secreted (RANTES) |
| CCL8 | M1 | Macrophage chemotactic protein 2 (MCP-2) |
| CCL11 | M1 | Eotaxin 1 |
| CCL13 | M1 | Chemokine (C-C motif) ligand 13 |
| CCL17 | M2 | Thymus and activation regulated chemokine (TARC) |
| CCL18 | M2 | Pulmonary and activation-regulated chemokine (PARC) |
| CCL19 | M1 | Macrophage inflammatory protein 3β (MIP-3β) |
| CCL20 | M1/M2 | Macrophage inflammatory protein 3α (MIP-3α) |
| CCL22 | M2 | Chemokine (C-C motif) ligand 22 |
| CCL23 | M2 | Macrophage inflammatory protein 3 (MIP-3) |
| CCL24 | M2 | Eotaxin 2 |
| CCR2 | M1 | CD192, receptor for CCL2 |
| CCR2B | M1 | Receptor for CCL2 |
| CCR7 | M1 | Receptor for CCL19 and CCL21 |
| CXCL1 | M2 | Gro1 |
| CXCL9 | M1 | Monokine induced by gamma interferon (MIG) |
| CXCL10 | M1 | Interferon gamma-induced protein 10 (IP-10) |
| CXCL11 | M1 | Interferon-inducible T-cell alpha chemoattractant (I-TAC) |
| CXCL13 | M1/M2 | Breast and kidney-expressed chemokine (BRAK) |
| CXCR1 | M1 | Chemokine (C-X-C motif) receptor 1 |
| CXCR2 | M1 | IL8 receptor B |
| CD11b | M2 | Integrin alpha M (ITGAM) |
| CD14 | M2 | Co-receptor for LPS |
| CD16 | M2 | Fc IgG receptor 3A |
| CD23 | M2 | Fc IgE receptor 2 |
| CD36 | M2 | Class B scavenger receptor |
| CD40 | M1 | Costimulatory protein found on APCs, binds CD154 (CD40L) |
| CD68 | M1/M2 | Binds to low density lipoprotein, highly expressed by human monocytes and tissue macrophages |
| CD80 | M1/M2 | Co-stimulatory molecule (B7–1) binds CD28 and CTLA-4 |
| CD86 | M1/M2 | Co-stimulatory molecule (B7–2) binds CD28 and CTLA-4 |
| CD163 | M2 | Scavenger receptor cysteine rich family type B |
| CD200R | M2 | CD200 receptor 1, receptor for the OX-2 membrane glycoprotein |
| CD209 | M2 | DC-SIGN, C-type lectin receptor |
| CERK | M2 | Ceramide kinase |
| CHI3L2 | M1 | Chitinase 3-like 2 |
| CLEC7A | M2 | Dectin 1 |
| DRB4 | M1/M2 | Major histocompatibility complex, class II, DR beta 4 |
| DQB1 | M1/M2 | Major histocompatibility complex, class II, DQ beta 1 |
| DMB | M1/M2 | Major histocompatibility complex, class II, DM beta |
| DQ1 | M1/M2 | Major histocompatibility complex, class II, DQ 1 |
| DMA | M1/M2 | Major histocompatibility complex, class II, DM alpha |
| DOA | M1/M2 | Major histocompatibility complex, class II, DO alpha |
| DOB | M1/M2 | Major histocompatibility complex, class II, DOR beta |
| DPA | M1/M2 | Major histocompatibility complex, class II, DP alpha |
| DPB | M1/M2 | Major histocompatibility complex, class II, DP beta |
| DQA1 | M1/M2 | Major histocompatibility complex, class II, DQ alpha |
| DRA | M1/M2 | Major histocompatibility complex, class II, DR alpha |
| ECGF1/TYMP | M1 | Thymidine phosphorylase |
| FAS | M1 | Fas cell surface death receptor |
| FN1 | M2 | Fibronectin 1 |
| GADD45G | M2 | Growth arrest and DNA-damage-inducible, gamma |
| GPR86 | M2 | Purinergic receptor P2Y, G-protein coupled, 13 |
| HEXB | M2 | Hexosaminidase B |
| HO-1 | M2 | Hemoxyganase 1 |
| HRH1 | M2 | Histamine receptor H1 |
| HSD11B1 | M1 | Hydroxysteroid (11-beta) dehydrogenase 1 |
| HS3ST1 | M2 | Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| IDO1 | M1 | Indoleamine 2,3-dioxygenase 1 |
| IGF1 | M2 | Instulin-like growth factor 1 |
| IFNA1 | M1 | Interferon, alpha 1 |
| IFNA2 | M1 | Interferon, alpha 2 |
| IFNA6 | M1 | Interferon, alpha 6 |
| IFNA13 | M1 | Interferon, alpha 13 |
| IFNA16 | M1 | Interferon, alpha 16 |
| IFNA21 | M1 | Interferon, alpha 21 |
| IFNB1 | M1 | Interferon, beta 1 |
| IL1B | M1/M2 | Interleukin 1 beta |
| IL1RN | M2 | Interleukin 1 receptor antagonist |
| IL1R1 | M1 | Interleukin 1 receptor 1 |
| IL1R2 | M2 | Interleukin 1 receptor 2 |
| IL6 | M1 | Interleukin 6 |
| IL8 | M1 | Interleukin 8 |
| IL10 | M2 | Interleukin 10 |
| IL12A | M1 | Interleukin 12 subunit alpha |
| IL12B | M1 | Interleukin 12 subunit beta |
| IL15 | M1 | Interleukin 15 |
| IL15RA | M1 | Interleukin 15 receptor, alpha |
| IL23A | M1 | Interleukin 23 subunit alpha |
| MAF | M2 | v-Maf avian musculoaponeurotic fibrosarcoma ongogene homolog A |
| MRC1 | M2 | Macrophage mannose receptor (CD206) |
| MRC1L1 | M2 | Mannose C-type lectin receptor |
| MSR1 | M2 | Macrophage scavenger receptor 1 (SR-A1) |
| MS4A4 | M2 | Membrane-spanning 4-domains, subfamily A, member 4 |
| MS4A6A | M2 | Membrane-spanning 4-domains, subfamily A, member 6A |
| NOS2 | M1 | Nitric oxide synthase 2 (inducible) |
| OAS1 | M1 | 2’-5’-oligoadenylate synthetase 2 |
| OASL | M1 | 2’-5’-oligoadenylate synthetase-like |
| PBEF1/NAMPT | M1 | Nicotinamide phosphoribosyltransferase |
| PFKFB3 | M1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| PFKP | M1 | Phosphofructokinase, platelet |
| PLA1A | M1 | Phospholipase A1 Member A |
| PPARG | M2 | Peroxisome proliferator-activated receptor gamma |
| PSMA2 | M1 | Proteasome subunit, alpha type, 2 |
| PSMB9 | M1 | Proteasome subunit, beta type, 9 |
| PSME2 | M1 | Proteasome activator subunit 2 (PA28 beta) |
| PTX3 | M1 | Pentraxin 3 |
| P2RY14 | M2 | Purinergic receptor P2Y, G-protein coupled, 14 |
| SCARA3 | M2 | Scavenger receptor class A, member 3 |
| SCARF2 | M2 | Scavenger receptor class F, member 2 |
| SEPP1 | M2 | Selenoprotein P, plasma, 1 |
| SRA | M2 | Macrophage scavenger receptor A (SR-A) |
| SLC2A6 | M1 | Solute Carrier Family 2 (Facilitiated Glucose Transporter), member 6 |
| SLC31A2 | M1 | Solute Carrier Family 31 (Copper Transporter), Member 2 |
| SLC7A5 | M1 | Solute Carrier Family 7 (Amino Acid Transporter Light Chain, L System), Member 5 |
| SPHK1 | M1 | Sphingosine kinase 1 |
| TGFB1 | M2 | Transforming growth factor beta 1 |
| TGFBR2 | M2 | Transforming growth factor beta receptor 2 |
| TLR2 | M1 | Toll-like receptor 2 |
| TLR4 | M1 | Toll-like receptor 4 |
| TLR5 | M2 | Toll-like receptor 5 |
| TNF | M1/M2 | Tumor necrosis factor alpha |
| TNFSF10 | M1 | TRAIL |