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. 2016 Mar 11;7:95. doi: 10.3389/fimmu.2016.00095

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Copyright © 2016 Ferreira, Mariano, Ghilosso-Bortolini, Arantes, Fernandes, Berni, Cecchinato, Uguccioni, Maj, Barberis, Silva and Martins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of intranasal treatment with TMX-306 on granuloma formation (upper panels) and collagen deposition (lower panels) in silica-challenged mice. Histological sections of mouse lungs on day 30 after silica challenge (B,E) and treated with TMX-306 (70 nmoles/mouse, intranasal) (C,F). Animals instilled with PBS were used as controls (A,D). Animals were treated with TMX-306 (70 nmoles/mouse, intranasal) days 15, 20, and 25 post-silica. Morphometric analyzes are seen in (G) granuloma area and (H) collagen deposition. Slides were stained with H&E (upper panels) and Picrosirius red (lower panels). Scale bars, 200 μm. Values represent mean ± SEM from at least five animals. ⁺P < 0.05 as compared to PBS-challenged group; *P < 0.05 as compared to silica-challenged group.