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. 2016 Mar 11;6:22803. doi: 10.1038/srep22803

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Schematic diagram showing the use of focused ultrasound to trigger local temperature change and compound release, using thermally responsive components inside an implantable device. Picture of the FUS transducer used in this study. The man silhouette drawing belongs to SC. (b) Schematic diagram showing the fabrication steps for the implantable microdevice. (c) Picture of a NiPAAm-based gel (80:20 NiPAAm:AAM, 5% MBAAM) fabricated by UV lithography with dimensions on the micron range (scale bar: 500 μm). (d) Cross-section diagram (top) and top-down photograph (bottom) showing ~20% contraction of the gel across 8 °C (scale bar: 1 mm).