Table 2. Mean concentrations of C3G and its derivatives in liver, kidneys and brain of Wistar rats following intravenous administration of 668 nmol of C3G.
| Time (min) | C3G (pmol/g) | PN3G (pmol/g) | PT3G (pmol/g) | isoPN3G (pmol/g) | |
| Liver | 0.25 | 56.61 ± 11.79 | 539.38 ± 71.33 | 1.23 ± 0.59# | 13.86 ± 4.32 |
| 2 | 19.22 ± 1.99 | 317.61 ± 35.86 | 2.42 ± 0.08 | 6.19 ± 2.09 | |
| 5 | 20.91 ± 2.61 | 364.74 ± 44.85 | 1.09 ± 0.52# | 15.85 ± 1.82 | |
| 15 | 11.02 ± 2.24 | 216.10 ± 36.06 | 1.60 ± 0.44# | 1.39 ± 1.14 | |
| 20 | 5.54 ± 0.33 | 100.84 ± 6.33 | 3.06 ± 0.19 | 0.64 ± 0.25# | |
| AUC0-t (pmol/g min) | 345.29 | 5610.12 | 33.85 | 145.57 | |
| Half-life (min) | 8.15 | 9.99 | nsd | 3.18 | |
| MTTL (min) | 1.43 | 3.93 | nsd | N/A | |
| Kidneys | Time (min) | C3G (nmol/g) | PN3G (nmol/g) | PT3G (pmol/g) | |
| 0.25 | 1.69 ± 0.47 | 1.99 ± 0.55 | 2.04 ± 0.59# | ||
| 2 | 1.40 ± 0.16 | 1.56 ± 0.18 | 2.82 ± 0.28 | ||
| 5 | 0.58 ± 0.08 | 0.85 ± 0.08 | 2.40 ± 0.13 | ||
| 15 | 0.57 ± 0.17 | 0.89 ± 0.22 | 2.29 ± 0.07 | ||
| 20 | 0.44 ± 0.04 | 0.90 ± 0.14 | 2.53 ± 0.26 | ||
| AUC0-t (nmol/g min) | 14.32 | 20.36 | 48.13* | ||
| Half-life (min) | 11.66 | 20.80 | 135.08 | ||
| MTTK (min) | 8.54 | 23.11 | 187.44 | ||
| Brain | Time (min) | C3G (pmol/g) | PN3G (pmol/g) | PT3G (pmol/g) | |
| 0.25 | 40.46 ± 9.67 | nd | nd | ||
| 2 | 7.48 ± 0.79 | 2.07 ± 1.18 | 1.15 ± 0.62# | ||
| 5 | 7.05 ± 0.55 | 0.70 ± 0.30# | 1.01 ± 0.46# | ||
| 15 | 2.18 ± 0.58 | 0.40 ± 0.38# | 2.45 ± 0.22 | ||
| 20 | 2.21 ± 0.44 | 0.37 ± 0.13# | 1.90 ± 0.60# | ||
| AUC0-t (pmol/g min) | 119.89 | 17.10 | 32.42 | ||
| Half-life (min) | 8.80 | 15.57 | nsd | ||
| MTTB (min) | 0.43 | 8.61 | nsd |
Concentrations are expressed as mean ± SEM (n = 4).
*pmol g–1 min–1; N/A Not applicable; nd, not detected.
#value below LOQ; nsd data not sufficient to estimate the terminal slope; AUC0-inf, Area under curve; MTTB, Mean Transit Time in the brain; MTTK, Mean Transit time in kidneys; MTTL, Mean Transit Time in the liver.