Table 1. New loci and independent SNPs associated with CLL risk.

SNP	Cytoband	Nearest gene	Position	Stage	No. of cases	No. of controls	Risk allele/other allele	RAF	OR	CI	P
New loci
rs9880772	3p24.1	EOMES	27777779	Discovery	3,097	7,664	T/C	0.464	1.17	(1.10–1.24)	7.77E−07
				Replication	1,935	5,414	T/C	0.467	1.23	(1.13–1.34)	4.67E−06
				Combined	5,032	13,078	T/C	0.465	1.19	(1.13–1.25)	2.55E−11
rs73718779	6p25.2	SERPINB6	2969278	Discovery	3,097	7,663	A/G	0.111	1.27	(1.16–1.40)	6.22E−07
				Replication	1,871	4,107	A/G	0.109	1.21	(1.05–1.40)	0.008
				Combined	4,968	11,770	A/G	0.110	1.26	(1.16–1.36)	1.97E−08
rs9815073	3q28	LPP	188115682	Discovery	3,098	7,663	C/A	0.651	1.20	(1.12–1.28)	5.35E−07
				Replication	1,848	4,094	C/A	0.652	1.13	(1.03–1.25)	0.01
				Combined	4,946	11,757	C/A	0.651	1.18	(1.11–1.25)	3.62E−08
New independent SNP at known locus
rs9308731	2q13	BCL2L11	111908262	Discovery	3,100	7,665	A/G	0.541	1.19	(1.12–1.26)	4.71E−08
				Replication	1,929	5,448	A/G	0.531	1.21	(1.10–1.32)	4.66E−05
				Combined	5,029	13,113	A/G	0.537	1.19	(1.13–1.26)	1.00E−11
New suggestive loci (P<5 × 10−7)
rs10028805	4q24	BANK1	102737250	Discovery	3,099	7,665	G/A	0.625	1.16	(1.09–1.23)	7.04E−06
				Replication	1,876	4,107	G/A	0.621	1.15	(1.05–1.15)	0.003
				Combined	4,975	11,772	G/A	0.624	1.16	(1.10–1.22)	7.19E−08
rs1274963	3p22.2	CSRNP1	39191029	Discovery	3,100	7,666	T/C	0.210	1.20	(1.12–1.29)	1.37E−06
				Replication	1,938	5,402	T/C	0.204	1.13	(1.01–1.26)	0.03
				Combined	5,038	13,068	T/C	0.208	1.18	(1.11–1.25)	2.12E−07

CI, confidence interval; OR, odds ratio; RAF, risk allele frequency among controls.