Figure 3.

Effect of direct in vivo plasmid vector-mediated mLDLR and mVLDLR gene transfers on plasma lipids in LDLR knockout mice. Changes in plasma (a) cholesterol and (b) triglyceride levels after the gene transfers via hydrodynamic tail vein injections. Data are expressed as percentage (mean ± SEM) change in comparison to the pretreatment values in each individual animal. Comparisons were performed to the levels of nontransfected control animals using two-way ANOVA, followed by Dunnet's posttest. *P < 0.05, **P < 0.01, ***P < 0.001.