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. 2016 Jan 26;24(3):536–547. doi: 10.1038/mt.2015.226

Figure 4.

Figure 4

Tumor suppressive effects of candidate TSGs. (a) Cell viability of HeLa cells after re-expression of silenced CCNA1 and TFPI2 by 12ab-VP64 and 43ab-VP64, respectively. (b) Cell viability of CC-11 cells after gene induction/upregulation of C13ORF18, CCNA1, TFPI2, and Maspin by 3ab-VP64, 12ab-VP64, 43ab-VP64, and 126-VP64, respectively. Cell proliferation was assessed using a MTS assay during 5 days and empty vector and ZFP-NoEf were used as controls. (c) Percentage of cell death after treatment with empty vector, C13ORF18-, CCNA1-, TFPI2-, and Maspin-cDNA overexpression constructs in CC-11 cells. Each data point represents the mean of three or more independent experiments measured in triplicate ± SEM.