Table 4.
Gene ontology (GO) biological processes among genes predicted in silico to be targeted by miRNAs associated with EDC burden (miR-185, miR-142-3p, miR-15a-5p).
| GO term | Annotated | Significant | Expected | p‑Value | FDR q‑value |
|---|---|---|---|---|---|
| Ubiquitin-dependent protein catabolic process | 403 | 39 | 17.43 | 3.50E-06 | 0.08 |
| Regulation of protein serine/threonine kinase activity | 366 | 35 | 15.83 | 1.90E-05 | 0.22 |
| Positive regulation of small GTPase mediated signal transduction | 30 | 8 | 1.3 | 2.90E-05 | 0.22 |
| Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 26 | 7 | 1.12 | 8.80E-05 | 0.51 |
| Heterophilic cell–cell adhesion | 29 | 7 | 1.25 | 1.90E-04 | 0.88 |
| Insulin-like growth factor receptor signaling pathway | 32 | 8 | 1.38 | 2.60E-04 | 0.93 |
| Axonal fasciculation | 15 | 5 | 0.65 | 3.10E-04 | 0.93 |
| Negative regulation of cellular macromolecule biosynthetic process | 948 | 64 | 41 | 3.20E-04 | 0.93 |
| Cellular response to insulin stimulus | 207 | 20 | 8.95 | 5.40E-04 | 1.00 |
| Regulation of sodium ion transmembrane transport | 25 | 6 | 1.08 | 5.60E-04 | 1.00 |
| Regulation of translational elongation | 10 | 4 | 0.43 | 5.90E-04 | 1.00 |
| Protein dephosphorylation | 140 | 16 | 6.05 | 6.20E-04 | 1.00 |
| Metencephalon development | 84 | 13 | 3.63 | 6.20E-04 | 1.00 |
| Embryonic epithelial tube formation | 106 | 13 | 4.58 | 6.50E-04 | 1.00 |
| Positive regulation of mesenchymal cell proliferation | 36 | 7 | 1.56 | 7.60E-04 | 1.00 |
| Platelet-derived growth factor receptor signaling pathway | 36 | 7 | 1.56 | 7.60E-04 | 1.00 |
| Smooth muscle tissue development | 18 | 5 | 0.78 | 8.00E-04 | 1.00 |
| Negative regulation of cell proliferation | 529 | 39 | 22.88 | 9.80E-04 | 1.00 |
| Neuron projection guidance | 347 | 30 | 15.01 | 9.90E-04 | 1.00 |
| FDR, false discovery rate. | |||||