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. 2016 Mar 11;9:58. doi: 10.1186/s13068-016-0466-5

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© Liu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Production of geraniol via the MVA pathways used in this study. Enzymes involved in this pathway: MvaE, E. faecalis acetyl-CoA acetyltransferase/HMG-CoA reductase; MvaS, E. faecalis HMG-CoA synthase; ERG12, S. cerevisiae mevalonate kinase; ERG8, S. cerevisiae phosphomevalonate kinase; ERG19, S. cerevisiae mevalonate pyrophosphate decarboxylase; IDI1, S. cerevisiae IPP isomerase; GPPS2, A. grandis geranyl diphosphate synthase; GES, O. basilicum synthase was optimized to the preferred codon usage of E. coli. Pathway intermediates: A-CoA, acetyl-CoA; AA-CoA, acetoacetyl-CoA; HMG-CoA, hydroxymethylglutaryl-CoA; Mev-P, mevalonate 5-phosphate; Mev-PP, mevalonate pyrophosphate. IPP isopentenyl pyrophosphate, DMAPP dimethylallyl pyrophosphate, GPP geranyl diphosphate