Table 4.
Comparison of AUCs characterized biomarker models to standard model calculated for LFEV less 40 %. The results of ROC curve analysis
| Models | AUC | 95 % CI | P values |
|---|---|---|---|
| Standard Model: LVEF | 0.646 | 0.612 – 0.661 | - |
| NT-pro-BNP | 0.683 | 0.644 – 0.703 | 0.045 |
| Galectin-3 | 0.731 | 0.711 – 0.754 | 0.013 |
| hs-CRP | 0.656 | 0.634 – 0.687 | 0.068 |
| Osteoprotegerin | 0.722 | 0.707 – 0.739 | 0.012 |
| sRANKL/osteoprotegerin ratio | 0.734 | 0.723 – 0.752 | 0.001 |
| CD14+CD309+Tie2 MPCs | 0.785 | 0.755 – 0.794 | 0.001 |
| CD31+/annexin V+ EMPs to CD14+CD309+ MPCs ratio | 0.834 | 0.805 – 0.861 | 0.001 |
Abbreviations: AUC area under curve, ROC receive operation characteristic, LVEF left ventricular ejection fraction, BNP brain natriuretic peptide, hs-CRP high sensitive C-reactive protein, sRANKL serum receptor activator of nuclear factor-kappa B ligand, EMPs endothelial-derived apoptotic microparticles, MPCs mononuclear progenitor cells