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. Author manuscript; available in PMC: 2016 Mar 11.
Published in final edited form as: Mol Cell. 2015 Jul 16;59(2):143–145. doi: 10.1016/j.molcel.2015.07.005

Figure 1. Different Strategies to Regulate 26S Abundance.

Figure 1

In this issue of Molecular Cell, Zhang et al describe the regulation of 20S assembly by controlling levels of a limiting chaperone, POMP/hUMP1 by the miR-101. This mode of regulation appears to be disrupted in at least some cancer types. Stem cells maintain high levels of 26S proteasomes by increasing transcription of a limiting subunit, Rpn6, under control of FoxO4. Cells that are treated with proteasome inhibitors and cells in certain types of proteotoxic stress compensate by inducing via the transcription factor Nrf1 all proteasome subunits plus POMP and other 20S assembly factors.