Table 2.
Results of the main studies to have used the self-administration paradigm to evaluate the reinforcing effects of psychostimulants in animals classified as high or low novelty seekers according to a free-choice NS paradigm.
| Novelty-Seeking Animal Model | Animals | Age | Drug | Main Results in Self-Administration | References |
|---|---|---|---|---|---|
| Novelty place preference | Male Sprague–Dawley rats | Adult 175–200 g 70-75 PND |
0.1 mg/kg/inf amphetamine FR1 and FR5 i.v. | HNS>LNS | Cain et al., 2005; Meyer et al. 2010 |
| Male Sprague–Dawley rats | Adult 250–300g | 0.3-0.8-1 mg/kg/inf cocaine FR1 i.v. | HNS>LNS | Beckmann et al., 2011; Belin et al., 2011 | |
| Male and female Sprague–Dawley rats | Adult male: 200–225 g Adult female: 150–175 g |
0.03-0.16 mg/kg/inf amphetamine FR1 to FR5 i.v. | HR=LR | Klebaur et al., 2001 | |
| Novel object test | Male Sprague–Dawley rats | Adult 10 weeks old | 0.1 ml of 0.25 mg methylphenidate per infusion FR1 i.v. | HNS >LNS | de la Peña et al., 2014 |
| Male Sprague–Dawley rats | Adult 175–200 g | 0.01 - 0.1 mg/kg/inf amphetamine FR1 to FR5 i.v. | HR=LR | Cain et al., 2005 | |
| Hole-board | Male diversity Outbred (DO) mice | Housing at 4 weeks old Adult | 1 mg/kg/infcocaine FR1 i.v. | HNS>LNS | Dickson et al., 2015 |