Table 3.

Results of the main studies to have used the CPP paradigm to evaluate the rewarding effects of psychostimulants in animals classified as high or low novelty seekers according to an inescapable NS paradigm.

Novelty-Seeking Animal Model	Animals	Age	Drug	Rewarding Effects of Psychostimulants in CPP	References
Locomotor response to novelty	Male Long Evans rats	PND 46 Adolescent PND 70 Adult	Amphetamine (0.5 or 1.0 mg/kg) i.p.	HR less sensitive to amphetamine CPP (%time)	Mathew et al., 2010
	Male Sprague-Dawley rats	290-330g Adult 200-225g Adult	Cocaine (5,10,12,15,20 mg/kg) i.p Amphetamine (0.4mg/kg) s.c	HR=LR acquired CPP	Gong et al., 1996 Kosten and Miserendino, 1998 Dietz et al., 2007 Capriles et al., 2012 Robinet et al., 1998
	C57BL/6J male mice	7-8 weeks Adult	Cocaine (4, 8, 12 mg/kg) i.p.	LR>HR in CPP at low doses	Brabant et al., 2005 Shimosato and Watanabe, 2003
	Male Slc:ddY mice	5 weeks Adolescent	Cocaine (5, 10, 20mg/kg) i.p.
	Male and female OF1 mice	PND 35 Adolescent PND 56 Young adult	Cocaine (1mg/kg) i.p.	10 min: young adult HNR>LNS 1h: HR young adult male=LR young adult female acquired CPP	Arenas et al., 2014