Table 4.
Results of the main studies to have used the CPP paradigm to evaluate the rewarding effects of psychostimulants in animals classified as high or low novelty seekers according to a free-choice NS paradigm.
| Novelty-Seeking Animal Model | Animals | Age | Drug | Rewarding Effects of Psychostimulants in CPP | Reference |
|---|---|---|---|---|---|
| Novel environment | Male Sprague- Dawley rats |
200-225g Adult |
Amphetamine (0.4 mg/kg) s.c. |
HR>LR higher magnitude of CPP | Robinet et al. 1998 |
| Novelty test chambers | Male Wistar rats | 180-200g Adult |
Amphetamine (0.2 – 3.2mg/kg) s.c. |
HR=LR acquired CPP at high doses HR>LR stronger CPP at the lowest dose |
Pelloux et al. 2004 |
| Novelty test chambers | Sprague- Dawley rats |
Adult | Amphetamine (0.75-10mg/kg) i.p. | HNS=LNS acquired CPP | Erb and Parker, 1994 |
| Playground maze | Male Sprague- Dawley rats |
200-225g Adult |
Amphetamine (1–3 mg/kg) s.c. | HNS>LNS amphetamine CPP (1 mg/kg). | Klebaur and Bardo, 1999 |
| Novel object recognition task Novel environment test |
Male and female OF1 mice | PND 35 Adolescent PND 56 Young adult |
Cocaine (1mg/kg) i.p. | HNS (Young adult)>LNS acquired CPP | Vidal-Infer et al., 2012 |
| Hole-board | Male and female OF1 mice | PND 35 Adolescent PND 56 Young adult |
Cocaine (1mg/kg) i.p. | HNS (adolescent) = LNS (young adult female) acquired CPP | Arenas et al., 2014 |
| Male OF1 mice | PND 31 Adolescent (binge) PND 67 Adult(CPP) |
Alcohol Binge (2.5g/kg) i.p. + Cocaine (CPP) (1 or 6mg/kg) i.p. MDMA (CPP) (1.25 or 2.5mg/kg) i.p. |
HNS=LNS acquisition CPP HNS reinstates cocaine CPP |
Montagud-Romero et al., 2014 | |
| PND 28/33 Adolescent (binge) PND 60/67 Adult (CPP) |
MDMA or Cocaine binge i.p. + Cocaine (CPP) (1mg/kg) i.p. MDMA (CPP) (1.25mg/kg) i.p. |
HNS>LNS acquired CPP with both drugs. | Rodríguez-Arias et al., 2015 Mateos-García et al., 2015 |