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Sites of enrichment that benefit from multiple lines of biological evidence are not lost in the presence of the sponge mapping targets, as shown monitor changes in read depth for (A) CTCF with increasing abundance of the sponge database (1x–8x coverage), (B) long RNA datasets that overlap with characterized RefSeq gene locations and (C) within promoter regions, defined here as 1 kb upstream of a RefSeq gene and evaluated using DNase, GABP and H3K4me3 datasets.
