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. 2015 Oct 19;43(20):9918–9927. doi: 10.1093/nar/gkv1067

Figure 6.

Figure 6.

Proposed model for Dpo4 bypassing adducts at the terminal DNA duplex. (A) Misaligned DNA structures that allow dTTP misincorporation. In a primer-template loop (left), the terminal primer base, dC, pairs with the downstream T, causing the adducted dG in the template to loop out. In a dNTP-stabilized misaligned structure (right), the incoming dTTP base pairs with the downstream A without looping out; (B) In the presence of AF, correct dATP incorporation is preferred with a terminal cognate base pair but in the presence of an A:G mismatch a primer-template slippage occurs, leading to dTTP misincorporation. A terminal G:G mismatch constitutes a dead end for AF. (C) In the presence of AAF, a dNTP-stabilized misalignment is preferred, leading to an increased dTTP misincorporation in all cases.