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. 2015 Aug 31;43(20):9928–9936. doi: 10.1093/nar/gkv860

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Spontaneous transitions between folded and unfolded hairpin states at constant extension. (Top panel) Force recorded on RNA10 (green) as a function of time, while the extension is constant apart from stepwise increases (black). Force flipping is observed for each extension value. (Second panel) Zoom on an extension where both states have a similar probability of occupation: the average dwell times are 1.77 s in the unfolded state and 3.1 s in the folded state. Presented time range: 80 s. (Third panel) Force recorded on DNA10 (orange) as a function of time, while the extension is constant apart from stepwise increases (black). Force flipping is observed for each extension value. (Bottom panel) Zoom on an extension where both states have a similar probability of occupation: the average dwell times are 0.11 s in the unfolded state and 0.25 s in the folded state. Presented time range: 10 s. The transition rate is much higher for DNA10 than for RNA10.