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. 2015 Aug 14;43(20):9766–9775. doi: 10.1093/nar/gkv837

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — A proposed CTD ‘code’ for co-transcriptional histone modifications. Grey ovals depicting the Rpb1 and Spt5 CTDs are positioned above the typical histone modification landscape of a transcribed gene (see (11)). The ovals are labeled with the specific phospho-sites implicated in each of the indicated histone modifications and are depicted as independent or overlapping. The sizes of the labels denote their relative functional importance for each histone modification. Arrows connect CTD kinases to functionally validated target phospho-sites. Broken arrow indicates negative regulation of H3K4me by Lsk1/Cdk12-dependent Rpb1 Ser2 phosphorylation.