Table 3. The top transcription factor binding sites (TFBSs) from LARVA's analysis of our 760 cancer genomes dataset.
| TF | Significant sites | Total sites | Percent |
|---|---|---|---|
| CTCF | 852 | 2 659 185 | 3.204 × 10−4 |
| RAD21 | 135 | 352 084 | 3.834 × 10−4 |
| MAFK | 93 | 112 704 | 8.252 × 10−4 |
| CEBPB | 77 | 111 585 | 6.901 × 10−4 |
| SPI1 | 55 | 81 054 | 6.786 × 10−4 |
| STAT3 | 45 | 140 552 | 3.203 × 10−4 |
| NR2C2 | 44 | 4557 | 9.656 × 10−4 |
| NFKB1 | 40 | 85 483 | 4.680 × 10−4 |
| MYC | 37 | 129 293 | 2.862 × 10−4 |
| SMC3 | 32 | 73 798 | 4.336 × 10−4 |
| MAX | 31 | 84 391 | 3.673 × 10−4 |
| JUND | 29 | 75 702 | 3.831 × 10−4 |
| BCL3 | 22 | 7926 | 2.776 × 10−3 |
| EP300 | 22 | 87 301 | 2.520 × 10−4 |
| FOXA1 | 22 | 88 985 | 2.472 × 10−4 |
| TFP.WRNIP1 | 1 | 2016 | 4.960 × 10−4 |
These findings may point to important regulatory disruptions in cancer.