Table 1. Classification of the 489 mutant strains displaying different degrees of respiratory growth impairment on YPE at 37°C and/or at 30°C.

Total number and type of mutants	HSa	MSa	LSa	New mutants	Human orthologsb
134 mutants respiratory growth-defective only at 37°C	58	52	24	65	52 (80%)
355 mutants respiratory growth-defective also at 30°C:
–268 mutants respiratory growth-defective at both 30°C and 37°C	221	26	21	22	16 (73%)
–87 mutants displaying a phenotype worsening effect at 37°Cc	56c	31c	—	18	8 (44%)

^aMutants were classified as high (HS), medium (MS) and low (LS) sensitive based on their serial dilution assay OXPHOS phenotypes (see also Figure 1A and Supplementary Table S1).

^bThe numbers (and percentages) of yeast genes with an orthologous counterpart in the human genome, only refers to the newly identified 105 genes that cause a respiratory growth defect when mutated.

^cNumber of mutants displaying a HS or MS OXPHOS phenotype at 37°C compared to a less severe phenotype at 30°C.