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. 2015 Aug 6;43(17):8540–8550. doi: 10.1093/nar/gkv801

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Sequence and structure of RNA domains interacting with FMRP. (A) Mouse and human sequence of G4RIF. The ACUK/WGGA motifs are highlighted in blue. (B) Six percent PAGE gel showing the running of retro transcribed G4RIF cDNA after treatment with DMS (modifying unpaired A and C) or CMCT (modifying unpaired G and U) (see also (6)). (C) RNA secondary structure model of G4RIF showing results from enzymatic cleavage and chemical modification experiments. The symbols indicating the reactivity are displayed and ACUK/WGGA sequences are shown in blue characters like in (A).