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Mutational frequency of dG-C8-IQ in the progeny from the G1, G2 and G3 constructs in HEK293T cells also transfected with NC siRNA (WT) or siRNA for single, double or triple pol(s) knockdowns (as indicated above the bar) is shown. The data represent the average of two independent experiments (presented in Supplementary Table S1 A–J in the SI).
