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The types and frequencies of mutations induced by dG-C8-IQ in the progeny from the G1, G2 and G3 constructs in HEK293T cells also transfected with NC siRNA (293T) or siRNA for double or triple pol(s) knockdowns are shown in a pie chart. D and O, respectively, represent targeted deletions and other mutations. The data represent the average of two independent experiments (presented in Supplementary Table S1 G–J in the SI).
