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. Author manuscript; available in PMC: 2016 Apr 20.
Published in final edited form as: Dev Cell. 2015 Apr 20;33(2):176–188. doi: 10.1016/j.devcel.2015.02.011

Figure 1. Proteomic Identification of BORC.

Figure 1

(A) Proteins that interact with BLOS2, LOH12CR1, or C17orf59 appended with OSF or FOS tags were identified by TAP-MS from HeLa (BLOS2) or H4 cells (LOH12CR1 and C17orf59). Selected prey proteins and their numbers of peptides detected in the MS are shown. The results suggest the existence of two complexes, BLOC-1 and BORC, that share BLOS1, BLOS2, and Snapin. KXD1 could also be a component of BLOC-1. The possibility that there could be variants of these complexes having different subunit combinations cannot be ruled out.

(B) Properties and orthologs of BORC subunits. AA, amino acid.

(C) Schematic of the overlapping subunit composition of BLOC-1 and BORC. New names for the previously uncharacterized subunits are shown in parenthesis. See also Figure S1 and Table S1.