Table 2. Analysis of rs1258763-subphenotype effect on the soft palate.
| Phenotype | Genotypes cases | MAF cases | Genotypes controls | MAF controls | P-value | RR allelic (95% CI) |
|---|---|---|---|---|---|---|
| nsCLP_hard+soft | 13/130/167 | 0.252 | 149/590/578 | 0.337 | 3.53×10−05 | 1.51 (1.24–1.85) |
| nsCLP_soft | 1/3/17 | 0.119 | 2.99×10−03 | 3.76 (1.47–9.61) | ||
| nsCPO_soft | 1/28/16 | 0.333 | 0.94 | 1.02 (0.65–1.59) | ||
| nsCPO_submuc | 12/55/48 | 0.343 | 0.85 | 0.97 (0.73–1.29) |
Abbreviations: MAF—minor allele frequency, RR—allelic odds ratio (provided for the risk allele A), CI—confidence interval, ns—non-syndromic, CLP—cleft lip and palate, CPO—cleft palate only, submuc—submucous. Genotypes are presented with the minor allele first, i.e. GG/AG/AA.