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. 2016 Mar 11;11(3):e0151224. doi: 10.1371/journal.pone.0151224

Fig 7. Time course of ejection fraction and non-HLA antibodies in two patients with AMR.

Fig 7

The solid line plots left ventricular ejection fraction and the dashed lines plot median fluorescence intensity minus background (MFI-B) of various antigens over time. Timing of VAD placement, heart transplant (Tx), and diagnosis of AMR are indicated above the graphs. Day of heart transplant is designated as Day 0. Graph shows mean ± SD for array features. (A) Patient AMR8. This patient developed IgM anti-tropomyosin and to a lesser extent IgM anti-DNA antibodies following transplant, which coincided with a drop in graft function. (B) Patient AMR6. This patient developed IgM anti-IgG antibodies (rheumatoid factor) following VAD placement, which decreased following heart transplant. A severe drop in graft function coincided with reappearance of rheumatoid factor. dsDNA, double-stranded DNA; LVEF, left ventricular ejection fraction; MFI-B, median fluorescence intensity minus background; ssDNA, single-stranded DNA; VAD, ventricular assist device.