Fig 2. Effects of the metabolic alteration on Disease and Bio Functions and Tox Functions predicted by IPA (p<0.05).

(A) The top five entries in three aspects of biological impact: Disease and Disorders, Molecular and Cellular Functions, and Hepatotoxicity. (B) Top altered canonical pathways predicted by IPA (p<0.005). The p values were calculated using Fischer's exact test determining the probability that the association between the genes in the data set and the canonical pathway was due to chance alone. The ratios were calculated based on the number of genes from the data set that mapped to the pathway and the total number of genes in the pathway.