Table 1. Pharmacokinetic data of MDMA.
| Cmax [μmol/l] | tmax [h] | AUC0-24h [μmol/l*h-1] | AUCtotal [μmol/l*h-1] | t1/2 [h] | CL/F [l/h] | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R | S | R/S | R | S | R | S | R/S | R | S | R | S | R | S | |
| MDMA | ||||||||||||||
| EM | 0.69 (0.17) | 0.56 (0.15) | 1.2 (0.1) | 2.9 (0.8) | 2.1 (0.7) | 8.7 (2.3) | 4.9 (1.4) | 1.8 (0.2) | 10.4 (3.6) | 5.1 (1.5) | 8.2 (2.4) | 4.5 (0.6) | 40.4 (14.2) | 72.8 (26.2) |
| IM | 0.85 (0.30) | 0.72 (0.23) | 1.2 (0.1) | 2.8 (0.9) | 2.3 (0.6) | 11.4 (3.3) | 6.8 (2.0) | 1.7 (0.1) | 14.5 (4.3) | 7.1 (2.0) | 10.3 (3.6) | 5.1 (0.9) | 29.8 (7.4) | 50.4 (12.6) |
| EM/Bup | 0.75 (0.16) | 0.65 (0.15) | 1.1 (0.1) | 3.3 (1.0) | 2.5 (0.6) | 10.9 (2.4) | 6.8 (1.5) | 1.6 (0.1) | 14.2 (3.7) | 7.2 (1.7) | 10.8 (1.9) | 5.7 (0.5) | 31.3 (8.2) | 50.5 (13.5) |
| MDA | ||||||||||||||
| EM | 0.014 (0.006) | 0.041 (0.012) | 0.3 (0.1) | 12.5 (8.1) | 4.6 (0.8) | 0.26 (0.10) | 0.61 (0.19) | 0.4 (0.1) | n.d. | 0.76 (0.27) | n.d. | 9.2 (2.3) | ||
| IM | 0.011 (0.002) | 0.042 (0.006) | 0.3 (0.0) | 18.7 (9.2) | 4.4 (0.5) | 0.21 (0.050) | 0.65 (0.15) | 0.3 (0.0) | n.d. | 0.87 (0.31) | n.d. | 10.6 (3.3) | ||
| EM/Bup | 0.010 (0.005) | 0.031 (0.007) | 0.3 (0.1) | 14.9 (8.8) | 5.2 (0.8) | 0.19 (0.076) | 0.49 (0.14) | 0.4 (0.1) | n.d. | 0.69 (0.17) | n.d. | 11.1 (1.8) | ||
| DHMA 3S | ||||||||||||||
| EM | 0.15 (0.080) | 0.59 (0.25) | 0.3 (0.1) | 2.8 (1.8) | 1.5 (0.3) | 2.4 (1.0) | 6.3 (2.7) | 0.4 (0.1) | 4.7 (2.5) | 7.1 (3.1) | 20.2 (6.2) | 7.3 (1.5) | ||
| IM | 0.055 (0.030) | 0.28 (0.11) | 0.2 (0.0) | 1.7 (0.9) | 1.9 (0.5) | 0.98 (0.64) | 3.0 (1.0) | 0.3 (0.1) | 2.6 (2.4) | 3.3 (1.1) | 27.4 (11.5) | 7.0 (0.4) | ||
| EM/Bup | 0.050 (0.025) | 0.20 (0.088) | 0.3 (0.1) | 3.8 (1.1) | 2.4 (0.6) | 0.96 (0.44) | 2.8 (1.3) | 0.4 (0.1) | 3.1 (2.1) | 3.7 (2.1) | 46.2 (32.5) | 11.3 (2.8) | ||
| DHMA 4S | ||||||||||||||
| EM | 0.080 (0.048) | 0.055 (0.025) | 1.5 (0.5) | 2.0 (0.8) | 1.7 (0.5) | 1.3 (0.74) | 0.64 (0.27) | 2.0 (0.7) | 2.4 (1.7) | 0.80 (0.37) | 17.5 (5.5) | 8.1 (1.2) | ||
| IM | 0.035 (0.005) | 0.029 (0.005) | 1.2 (0.1) | 3.0 (1.5) | 2.1 (0.5) | 0.54 (0.14) | 0.40 (0.11) | 1.5 (0.6) | 1.5 (1.0) | 0.59 (0.30) | 18.7 (15.6) | 12.1 (5.0) | ||
| EM/Bup | 0.037 (0.015) | 0.021 (0.007) | 1.7 (0.6) | 3.2 (1.1) | 2.4 (0.9) | 0.71 (0.30) | 0.32 (0.11) | 2.1 (0.7) | 2.9 (2.2) | 0.48 (0.19) | 49.9 (29.3) | 14.3 (3.6) | ||
| HMMA S | ||||||||||||||
| EM | 0.37 (0.11) | 0.41 (0.13) | 0.9 (0.2) | 2.0 (1.3) | 1.6 (0.5) | 5.5 (1.4) | 4.2 (1.2) | 1.3 (0.2) | 9.6 (2.7) | 4.6 (1.2) | 17.5 (6.6) | 6.6 (0.80) | ||
| IM | 0.10 (0.041) | 0.14 (0.022) | 0.7 (0.2) | 1.7 (0.8) | 2.5 (0.3) | 1.7 (0.70) | 1.7 (0.30) | 1.0 (0.3) | 3.4 (1.3) | 1.9 (0.34) | 21.2 (0.40) | 6.9 (0.50) | ||
| EM/Bup | 0.14 (0.039) | 0.11 (0.033) | 1.1 (0.2) | 4.2 (1.1) | 2.8 (0.6) | 2.1 (0.67) | 1.6 (0.51) | 1.3 (0.4) | 7.1 (4.6) | 2.2 (0.75) | 34.4 (23.9) | 11.1 (2.5) | ||
| HMMA G | ||||||||||||||
| EM | 0.21 (0.19) | 0.49 (0.39) | 0.5 (0.2) | 3.7 (2.1) | 2.9 (1.0) | 3.3 (2.1) | 5.2 (3.7) | 0.6 (0.2) | 5.5 (4.3) | 5.5 (3.9) | 16.0 (7.9) | 6.1 (1.2) | ||
| IM | 0.043 (0.038) | 0.099 (0.060) | 0.4 (0.1) | 4.8 (0.5) | 4.0 (0.1) | 0.84 (0.74) | 1.3 (0.77) | 0.6 (0.2) | 2.0 (1.7) | 1.5 (0.83) | 29.3 (12.4) | 7.1 (0.4) | ||
| EM/Bup | 0.049 (0.027) | 0.088 (0.044) | 0.6 (0.1) | 7.6 (1.2) | 4.9 (1.0) | 0.96 (0.54) | 1.3 (0.78) | 0.7 (0.1) | 2.3 (1.5) | 1.7 (1.0) | 31.7 (16.8) | 9.0 (2.8) | ||