Table 2. Pharmacokinetic data of Bupropion (P placebo, M MDMA).
| Genotype CYP2B6 | Cmax [ng/ml] | tmax [h] | AUC0-24h [ng/ml*h-1] | AUCtotal [ng/ml*h-1] | t1/2 [h] | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| R/ R,R | S/ S,S | R/ R,R | S/ S,S | R/ R,R | S/ S,S | R/ R,R | S/ S,S | R/ R,R | S/ S,S | ||
| Bupropion | |||||||||||
| P | normal | 51.2 (6.0) | 22.8 (12.3) | 5.0 (2.1) | 5.0 (1.4) | 807 (387) | 346 (172) | 942 (444) | 390 (186) | 8.4 (1.8) | 7.3 (1.6) |
| P | reduced | 68.0 (15.6) | 28.6 (3.8) | 5.8 (2.5) | 5.2 (0.6) | 1099 (112) | 442 (52.6) | 1334 (253) | 518 (110) | 8.9 (2.9) | 7.8 (2.8) |
| M | normal | 53.5 (19.4) | 21.9 (6.7) | 5.2 (2.6) | 6.2 (2.4) | 822 (237) | 344 (75.1) | 969 (284) | 395 (109) | 8.5 (3.3) | 7.5 (2.7) |
| M | reduced | 68.7 (23.6) | 31.4 (17.0) | 5.6 (2.3) | 4.7 (1.3) | 1139 (551) | 469 (290) | 1313 (669) | 533 (339) | 7.5 (1.7) | 6.8 (1.8) |
| HO-Bupropion | |||||||||||
| P | normal | 542 (145) | 26.7 (2.6) | 12.3 (5.2) | 8.4 (1.7) | 13778 (4205) | 567 (81.7) | n.d. | n.d. | n.d. | n.d. |
| P | reduced | 358 (53.3) | 18.6 (6.2) | 16.9 (7.6) | 9.6 (3.3) | 9082 (1685) | 417 (131) | n.d. | n.d. | n.d. | n.d. |
| M | normal | 479 (180) | 29.4 (13.6) | 13.0 (7.2) | 7.8 (2.7) | 11692 (3122) | 521 (187) | n.d. | n.d. | n.d. | n.d. |
| M | reduced | 452 (180) | 29.6 (10.0) | 11.7 (4.6) | 8.5 (1.4) | 10527 (5561) | 626 (212) | n.d. | n.d. | n.d. | n.d. |