Figure 7.
Cell-autonomous expression of heparan sulfate proteoglycans reveals opposing roles for SDN-1 and glypicans in AIY primary neurite outgrowth. Primary neurite defects in kal-1(gf) HSPG null mutants bearing transgenic rescue arrays. sdn-1(zh20) animals contain P-AIY-sdn-1::GFP transgenes. gpn-1(ok377) animals contain P-gpn-1-gpn-1::GFP or P-AIY-gpn-1::GFP transgenes. lon-2(e678) animals contain P-AIY-lon-2 transgenes. sdn-1::GFP and gpn-1::GFP transgenes were previously shown to be functional (Hudson et al. 2006). HSPG null mutant data from Figure 6 are included for comparison. Statistical significance was determined using the Z-test. *P < 0.05; **P < 0.01; ***P < 0.001. Error bars are standard error of proportion.