Fig 6. TEM of E. multilocularis metacestode exposed to 1.6 μM MMV665807 for 5 days.

Largely non-viable metacestode tissue is seen. (A) shows the separation of the laminated layer (LL) from the tegument (Te) (marked with +), and undifferentiated cells (uc) with a nucleus that is largely consisting of condensed chromatin. Arrows in (A) point towards microtriches, ld in (B) = lipid droplet. (C) shows a metacestode tissue exhibiting large scale necrosis, with the cytoplasm of the tegument being filled with large and small vacuoles of differing content. Arrows in (C) point towards microtriches. Bars in (A) = 4 μm, (B) = 1.5 μm, (C) = 3 μm.