Table 2. Model parameters.

	Isoniazid	Rifampicin	Pyrazinamide	Ethambutol	Streptomycin
Half-Life (h-1)	FAa: 1.54 ± 0.30 [86]	2.46 [86]	9.6 ± 1.8 [86]	2.6 [87]	3 [88,89]
	SAa: 3.68 ± 0.59 [86]
Dose (mg/L)	FAa: 2.80 ± 0.71b [89]	13.61 ± 3.96 [89]	29.21 ± 4.35 [89]	5.0 [87]	35–45 [14,89]
	SAa: 4.26 ± 0.94 b [89]
MIC (mg/L)	0.025 [57]	0.4 [57]	28 [58]	1.0 [57]	0.5 [54,56]
EC50 (mg/L)	0.033 d	0.51 d	40 c	0.20 d	0.32 d
Emax	1.86 d	1.82 d	1.94 d	0.96 d	1.31 d
CELF/CSerum (ρ) e	FAa: 1.74–5.88 [90]	0.34 [90]	13.60–24.76 [90]	0.92–1.13 [90]	1 c
	SAa: 1.37–5.69 [90]
Resistance frequency	2.56 · 10−8–10−7 [42,43]	2.25 · 10−10–10−8 [42,43]	10−9–10−8 c	10−7 [42]	2.95 · 10−8–10−7 [42],c
Resistance cost	0.1 [49]	0.1 [50,51]	0.1 [49]	0.1 c	0.1 [49,50]

Some of the provided references support the order of magnitude of the parameters, not the exact value.

^a FA = fast acetylators, SA = slow acetylators

^b If isoniazid is administered three times a week instead of daily the dosage is three times higher [14,91]

^c estimation

^d see text

^e ELF = epithelial lining fluid