Table 2. Disease categories associated with psoriasis based on the genes involved.
| Disease class | Disease | # genes | Genes involved |
|---|---|---|---|
| Musculoskeletal Diseases | RA | 16 | PLAT, MMP9, TLR2, GGH, PTPN22, CXCR2, MMP1, MMP12, TYMS, IL12RB1, CCR5, CD274, IL1B, SERPINA1, FCGR3B, SELE |
| Neoplasms | Esophageal cancer | 4 | TYMS, IL8, CXCR2, MMP1 |
| Neoplasms | Stomach Neoplasms | 5 | TYMS, IL8, CXCR2, MMP1 |
| Neoplasms | Leiomyoma | 3 | IL12RB1, IL8, IL1B |
| Neoplasms | Oral cancer | 5 | IL8, MMP9, TGFA, CYP2E1, MMP1 |
| Virus Diseases | Hepatitis C | 10 | IFI27, IL12RB1, CCR5, LDLR, IL19, IL1B, OAS1, CXCR2, MX1, IL20 |
| Virus Diseases | Hepatitis B | 6 | CCR5, OAS3, OAS1, OAS2, MX1, STAT1 |
| Otorhinolaryngologic Diseases | Hearing loss/deafness | 5 | PLAT, SLC26A4, GJB6, ESPN, GJB2 |
| Bacterial Infections and Mycoses | Tuberculosis | 9 | IL12RB1, IL8, TLR2, PTPN22, IL1B, CXCR2, SERPINA1, CYP2E1, STAT1 |
| Nervous System Diseases | Subarachnoid hemorrhage | 5 | MMP9, SERPINA3, IL1B, MMP12, MMP1 |
| Nervous System Diseases | Multiple sclerosis | 15 | IL8, MMP9, CCR1, APOC1, PTPN22, CXCR2, OAS1, IL7R, CXCL10, CCR5, IL1B, CD24, MX1, FCGR3B, SELE |
| Nervous System Diseases | AD | 3 | C3,CD14, DNM3 |
| Digestive System Diseases | Pancreatitis, chronic | 5 | IL8, PRSS2, PRSS3, SERPINA3, IL1B |
| Stomatognathic Diseases | Periodontitis | 9 | PLAT, CCR5, S100A8, MMP9, TLR2, IL1B, SERPINA1, FCGR3B, MMP1 |
| Respiratory Tract Diseases | COPD | 7 | IL8, MMP9, SERPINA3, IL1B, SERPINA1, MMP12, MMP1 |
| Respiratory Tract Diseases | Asthma | 15 | CYP2J2, MMP9, TLR2, CXCR2, EHF, IL12RB2, CCR5, CXCR4, FCGR1B, SERPINA3, FUT3, IL1B, SERPINA1, FUT2, SELE |
| Cardiovascular Diseases | Atherosclerosis | 13 | PLAT, F12, CYP2J2, LDLR, CCR5, SELL, MMP9, APOC1, TLR2, IL1B, FCGR3B, SELE, MMP1 |
| Cardiovascular Diseases | MI | 3 | JAK2, CD14, CCL1 |
| Cardiovascular Diseases | Coronary artery disease | 7 | PLAT, CCR5, LDLR, MMP9, IL1B, SELE, MMP12 |
| Digestive System Diseases | Cirrhosis; pancreatitis | 3 | IL8, IL1B, CYP2E1 |
| Skin and Connective Tissue Diseases | Systemic lupus erythematosus | 9 | CCR5, IL8, CFB, TLR2, PTPN22, IL1B, CXCR2, FCGR3B, SELE |
| Hemic and Lymphatic Diseases | Sarcoidosis; tuberculosis | 3 | IL12RB2, IL12RB1, MMP1 |
| Nutritional and Metabolic Diseases | T2DM | 2 | IL12RB2, IL12RB1 |
| Nutritional and Metabolic Diseases | Obesity | 5 | CXCL1, DPN, NAIP, PAPPA, IL24 |
#Number of genes enriched in each disease category; Diseases are classified based on the MeSH disease hierarchy