Fig 3. Total and H. felis-specific immunoglobulin levels in infected and uninfected mice.

Sera from infected mice were collected 12 weeks after infection with H. felis and antibody titers were determined by ELISA. (A-B) Total immunoglobulin levels were elevated to similar extent in both infected genotypes as compared to their uninfected littermates while (C, D) H. felis-specific immunoglobulin levels were decreased in infected Plcg2^Ali5/+ mice. Data represent mean ± SEM of 3 independent experiments including n = 14 to 15 infected Plcg2^Ali5/+ mice and n = 15 infected WT mice. Two independent experiments were done for uninfected mice (n = 4 per genotype). Data were analyzed by using the Mann-Whitney U-test. LU = labor units; ns = not significant. *p ≤ 0.05; **p ≤ 0.01.