Table 1. Histopathological results of H. felis-infected Balb/c Plcg2Ali5/+ and WT mice.
Group | Time post-infection [months] | Genotype | Number of mice | Normal findings | Lymphoid aggregates | MALT lymphoma | |
---|---|---|---|---|---|---|---|
Enrolledd | Diede | ||||||
1a | 6 | Plcg2 Ali5/+ | 11 | 1 | 40% (4/10) | 60% (6/10) | 0% |
WT | 11 | 0 | 46% (5/11) | 54% (6/11) | 0% | ||
2b | 12 | Plcg2 Ali5/+ | 16 | 1 | 0% | 67% (10/15) | 33% (5/15) |
WT | 16 | 1 | 0% | 33% (5/15) | 67% (10/15) | ||
3c | 16 | Plcg2 Ali5/+ | 17 | 3 | 0% | 50% (7/14) | 50% (7/14) |
WT | 17 | 2 | 0% | 7% (1/15) | 93% (14/15) |
BALB/c Plcg2Ali5/+ and WT mice were orally infected with H. felis on day 1, 3 and 5 and followed-up for 6, 12 and 16 months. Normal finding indicates healthy gastric mucosa.
Statistical analysis was done with Fisher´s exact test for
a, (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 1
b, (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 0.1431
c (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 0.0142
d Number of mice enrolled at the beginning of the study.
e Number of mice that died/killed during the study (within 6 months after infection).