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. 2016 Mar 11;11(3):e0150411. doi: 10.1371/journal.pone.0150411

Table 1. Histopathological results of H. felis-infected Balb/c Plcg2Ali5/+ and WT mice.

Group Time post-infection [months] Genotype Number of mice Normal findings Lymphoid aggregates MALT lymphoma
Enrolledd Diede
1a 6 Plcg2 Ali5/+ 11 1 40% (4/10) 60% (6/10) 0%
WT 11 0 46% (5/11) 54% (6/11) 0%
2b 12 Plcg2 Ali5/+ 16 1 0% 67% (10/15) 33% (5/15)
WT 16 1 0% 33% (5/15) 67% (10/15)
3c 16 Plcg2 Ali5/+ 17 3 0% 50% (7/14) 50% (7/14)
WT 17 2 0% 7% (1/15) 93% (14/15)

BALB/c Plcg2Ali5/+ and WT mice were orally infected with H. felis on day 1, 3 and 5 and followed-up for 6, 12 and 16 months. Normal finding indicates healthy gastric mucosa.

Statistical analysis was done with Fisher´s exact test for

a, (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 1

b, (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 0.1431

c (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 0.0142

d Number of mice enrolled at the beginning of the study.

e Number of mice that died/killed during the study (within 6 months after infection).