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. 2016 Mar 11;11(3):e0150411. doi: 10.1371/journal.pone.0150411

Table 2. Histopathological results of H. felis re-infected BALB/c Plcg2Ali5/+ and WT mice.

Group Re-infection Genotype Number of mice Normal findings Lymphoid aggregates MALT lymphoma
Enrolleda Diedb
4 4 times within 12 months Plcg2 Ali5/+ 11 1 40% (4/10) 60% (6/10) 0%
WT 11 0 46% (5/11) 54% (6/11) 0%

BALB/c Plcg2Ali5/+ and WT mice were orally infected with H. felis. Mice were re-infected with H. felis in a 3 months interval for totally 12 months. Normal finding indicates healthy gastric mucosa.

Statistical analysis was done with Fisher´s exact test (comparison of genotypes for MALT lymphoma development with lymphoid aggregates) Plcg2Ali5/+ versus WT mice p = 1.

a Number of mice enrolled at the beginning of the study.

b Number of mice that died during infection time. A histological investigation of these mice was not possible.