Table 3. Regulation of proinflammatory genes in whole peripheral blood of infected and uninfected mice.
| Comparison | Genes | Mean Fold Regulation* | Mean p-value |
|---|---|---|---|
| Uninfected Plcg2Ali5/+ vs. uninfected WT | Cebpb | +2.187 | 0.0100 |
| Cxcl1 | +2.851 | 0.0010 | |
| Cxcr1 | +3.997 | 0.0107 | |
| Il-18 | +5.613 | 0.0252 | |
| S100a8 | +2.614 | 0.0139 | |
| Tlr2 | +3.229 | 0.0024 | |
| Tnfsf13 | +3.742 | 0.0001 | |
| Tnfrsf13c | -2.295 | 0.0140 | |
| Tnfrsf17 | -3.559 | 0.0209 | |
| Infected Plcg2Ali5/+ vs. infected WT | Ccl3 | -2.841 | 0.0002 |
| Ccl4 | -2.059 | 0.0037 | |
| Ccl5 | -2.331 | 0.0113 | |
| Ccl20 | -3.661 | 0.0292 | |
| Cxcl1 | -2.201 | 0.0153 | |
| Ifng | -2.677 | 0.0421 | |
| Il-1a | -2.898 | 0.0010 | |
| Tnfrsf13c | -3.112 | 0.0052 | |
| Infected Plcg2Ali5/+ vs. uninfected Plcg2Ali5/+ | Ccl3 | -2.009 | 0.0498 |
| Ccl22 | -2.372 | 0.0114 | |
| Cxcl1 | -2.187 | 0.0044 | |
| Cxcl9 | -2.175 | 0.0008 | |
| Cxcl10 | -2.069 | 0.0227 | |
| Cxcr1 | -2.326 | 0.0042 | |
| Il-18 | -5.676 | 0.0043 | |
| Tlr2 | -2.159 | 0.0005 | |
| Tlr3 | -2.059 | 0.0009 | |
| Tnfsf13 | -3.347 | 0.0003 |
Gene expression was determined by using RT2 Profiler PCR array data analysis v3.5 software. Statistical analysis was done with unpaired t-test (p ≤ 0.05). Uninfected mice: n = 4 per genotype; infected mice: n = 7 per genotype.
+, fold upregulation
-, fold downregulation (e.g. Cebpb is upregulated in uninfected Plcg2Ali5/+ mice and Tnfrsf13c is downregulated in uninfected Plcg2Ali5/+ mice).
* Mean Fold Regulation of uninfected or infected mice.