Table 2.
Postoperative outcome measures in the studies included in the meta-analysis of femtosecond lasers for LASIK
| References (author, year) | Surgical procedure | Primary outcomes
|
Secondary outcomes
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Eyes (n) | Efficacy (%) | Predictability (%) | Safety (%) | Eyes (n) | Target flap thickness (µm) | Measured flap thickness (µm) ± SD (range) | Method | Intraop complication (%) | Postop complication (%) | ||
| Tran et al, 200520 | IntraLase FS 10 kHz | 7 | 100 | – | 0 | 8 | 120 | – | – | 0 | 37.5 |
| Durrie and Stahl, 200432 | IntraLase FS 15 kHz | 30 | 93 | 83 | 0 | 30 | 110 | – | – | – | – |
| 30 | 90 | 93 | 0 | 30 | 110 | ||||||
| Javaloy et al, 200733 | IntraLase FS 15 kHz | 100 | 80a | 83 | 1 | 20 | 120 | 130.14±1.70 | CM | 0 | 17 |
| Chan et al, 200834 | IntraLase FS 15 kHz | 40 | 98 | 93 | 3 | 51 | 120 | 118.7±12.2 | SUP | 0 | 28 (<1 mo) |
| Durrie and Kezirian, 200550 | IntraLase FS 15 kHz | 51 | 98 | 90 | – | 51 | 118 | – | – | – | – |
| Montes-Mico et al, 200721 | IntraLase FS 30 kHz | 100 | 100 | 98 | 0 | 100 | 120 | – | – | – | – |
| Patel et al, 200741 | IntraLase FS 15 kHz 21 | 0.01±0.11LogMar (20/20) | 90 | 0.06±0.09LogMar (20/15) | 21 | 120 | 143±16 (110–172) | CM | 0 | 0 | |
| Munoz et al, 201035 | IntraLase FS 15 kHz 48 | 85.4 | 97.9 | 0 | 48 | 120 | – | – | 0 | 0 | |
| Stonecipher and Kezirian, 200836 | IntraLase FS 15 kHz 188 | 93 (WF guided) | 93 | 0 | 374 | 100–130 | – | – | – | – | |
| 186 | 93 (WF optimized) | 94 | 0 | ||||||||
| Alio and Pinero, 200831 | IntraLase FS 30 kHz | 22 | – | 86.4a | 13.6a | 22 | 110 | 115.95±6.22 | VHF | 0 | 0 |
| Pfaeffl et al, 200837 | IntraLase FS 30 kHz | 287 | – | – | 0 | 287 | 100 | 100.4±13.6 (57–138) | OCP | 0 | 2.8 |
| Rosa et al, 200938 | IntraLase FS 60 kHz | 20 | 0.02±0.04LogMar | – | – | 20 | 120 | 143.1±18.4 (107.2–172.5) | SUP | – | – |
| 20 | 0.04±0.03LogMar | 20 | 120 | 115.5±12.5 (91.6–147.8)20 minutes | |||||||
| Slade et al, 200913 | IntraLase FS 60 kHz | 50 | 92 | – | 0 | 25 | 100 | 112±5 (87–118) | OCT | 0 | 0 |
| Prakash et al, 201014 | IntraLase FS 60 kHz | 60 | 97 | 91.6 | 0 | 60 | 90 | 89.97±4.12 | OCT | 3.3 | 1.7 |
| 60 | 80 | 90 | 0 | 60 | 100 | 99.96±5.30 | 5 | 3.3 | |||
| 60 | 82 | 91.6 | 0 | 60 | 110 | 110.01±4.50 | 6.7 | 1.7 | |||
| 60 | 87 | 93.3 | 0 | 60 | 120 | 119.26±4.94 | 3.3 | 1.7 | |||
| Hatch et al, 201115 | IntraLase FS 60 kHz | 25 | 92 | 88 | 0 | 26 | 90 | – | – | 11.5 | 23.1 |
| Prakash et al, 201116 | IntraLase FS 60 kHz | 368 | 82 | 95.1 | 0 | 368 | 90 | 90.1±6.7 (76–102) | OCT | 0 | 0 |
| 368 | 81 | 94.02 | 0 | 368 | 100 | 100.6±6.9 (85–114) | 0 | 0 | |||
| He et al, 201417 | IntraLase FS 60 kHz | 54 | 87 | 80 | 0 | 54 | 105 | – (WF guided) | SUP | 0 | 0 |
| 54 | 78 | 72 | 1.9 | 54 | 105 | – (WF optimized) | |||||
| Zhai et al, 201339 | IntraLase FS 60 kHz | 59 | – | – | – | 59 | 110 | 111±3 (104–120) | OCT | – | – |
| Tanzer et al, 201322 | IntraLase FS 60 kHz or 150 kHz | 497 | 98.2 | – | 0.4 | 544 | – | – | – | 0.2 | 0.2 |
| 48 | 100 | – | 0 | 57 | – | – | – | ||||
| 23b | 95.7b | – | 0b | 30 | – | – | – | ||||
| Yu and Manche, 201519 | IntraLase FS 60 kHz | 61 | 93 | 95 | 2 | 61 | 105 | – | – | 0 | 0 |
| IntraLase FS 150 kHz | 61 | 95 | 90 | 0 | 61 | 105 | – | – | 0 | 0 | |
| Sales and Manche, 201323 | IntraLase FS 150 kHz | 34 | 97 | 94 | 0 | 34 | 105 | – (WF guided) | SUP | – | – |
| 34 | 97 | 85 | 0 | 34 | 105 | – (WF optimized) | |||||
| Yu and Manche, 201425 | IntraLase FS 150 kHz | 50 | 97.9 | 100 | 0 | 50 | 105 | – (Allegretto Wave Eye-Q) | SUP | – | – |
| 50 | 91.5 | 92 | 0 | 50 | 105 | – (Visx Star Customvue S4 IR) | |||||
| Vryghem et al, 201026 | FEMTO LDV | 111 | 94.6 | 95.5 | 0 | 111 | 110 | 106.68±12.68 (84–149) | SUP | 17.1 | 14.4 |
| Zhou et al, 201242 | FEMTO LDV | 360 | – | – | – | 360 | 110 | 103.95±6.11 | OCT | – | – |
| Rosman et al, 201324 | Visumax 500 kHz | 39 | 79.5 | 89.7 | 0 | 45 | 115 | – | SUP | 13.3 | 0 |
| IntraLase FS 150 kHz | 39 | 82.1 | 84.6 | 0 | 45 | 110 | – | 2.2 | 0 | ||
| Ang et al, 201318 | Visumax 500 kHz | 381 | 75.5 | 86.9 | – | 381 | 110–120 | – | – | 2.1 | 0.3 |
| IntraLase FS 60 kHz | 362 | 75.0 | 87.3 | – | 362 | 100–110 | – | 0.3 | 0.6 | ||
| Lim et al, 201328 | Visumax 200 kHz | 36 | 95.8 | 100c | 0 | 36 | 80 | 83.46±3.50 (73–95) | OCT | Only OBL | |
| 36 | 100 | 97.1 | 0 | 36 | 120 | 122.93±3.55 (107–131) | Only OBL | ||||
| Kymionis et al, 201329 | Wavelight AG/Alcon | 42 | 86 | 86 | 0 | 42 | 105 | 102.98±6.33 (91–114) | OCT | 4.8 | 0 |
| FS200 | |||||||||||
| Cummings et al, 201330 | Wavelight FS200 | 378 | 83.4 | 91.0 | 0.3 | 431 | 120 | 120.23±13.94 (73–176) | SOP | 0 | 0 |
| 53b | 46.4b | 71.0b | 7.5b | ||||||||
| Ahn et al, 201140 | IntraLase FS 60 kHz | 50 | – | – | – | 50 | 110 | 103.3±13.2 | OCT | – | – |
| Visumax | 40 | – | – | – | 40 | 110 | 133.9±13.9 | ||||
| FEMTO LDV | 64 | – | – | – | 64 | 110 | 105.8±8.2 | ||||
| Arbelaez et al, 200927 | FEMTO LDV | 50 | 84 | 76d | 0 | 50 | 110 | – | SOP | 0 | 0 |
Notes: –, not reported;
a
estimated from a figure;
b
hyperopic eyes were excluded;
c
refraction within the ±0.25 D of target refraction;
d
only astigmatism correction. Studies written in bold have been included in the previously published meta-analyses.10,11
Abbreviations: CM, confocal microscopy; LASIK, laser-assisted in situ keratomileusis; OBL, opaque bubble layer; OCP, optical coherence pachymetry; OCT, optical coherence tomography; SD, standard deviation; SOP, subtraction online pachymetry, difference between preoperative corneal thickness and the thickness of corneal bed after flap lifting; SUP, subtraction ultrasound pachymetry; VHF, very-high-frequency digital ultrasound; WF, wave front; postop, postoperative; intraop, intraoperative; mo, month.