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. 2016 Mar 7;11:905–918. doi: 10.2147/IJN.S100350

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© 2016 Sun et al. This work is published and licensed by Dove Medical Press Limited

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Expression of gstp1, cyp1a, tnfα, and sod1 mRNA, TNFα and SOD1 protein and measurement of SOD activity.

Notes: (A and B) Expression of gstp1 and cyp1a mRNA in unexposed groups and copper oxide nanoparticle-exposed groups at concentrations of 1, 6.25, 12.5, 25, or 50 mg/L. (C and D) Expression of tnfα and sod1 mRNA in the unexposed, 12.5 mg/L exposed, and 50 mg/L exposed embryos. (E) Expression of TNFα and SOD1 proteins at 72 hours postfertilization. Note that (F) TNFα protein expression was increased, whereas (G) SOD1 protein expression was decreased in the 50 mg/L exposed group. (H) The result for the SOD activity assay. Note that SOD activity significantly decreased in the 50 mg/L exposed group (analysis of variance, *P<0.05).

Abbreviations: mRNA, messenger RNA; SOD, superoxide dismutase; TNFα, tumor necrosis factor alpha; GADPH, glyceraldehyde-3-phosphate dehydrogenase.